"High-fructose corn syrup causes characteristics of obesity in rats: Increased body weight, body fat and triglyceride levels", published in Pharmacology Biochemistry and Behavior, doi: 10.1016/j.pbb.2010.02.012:
In Experiment 1, male Sprague–Dawley rats were maintained for short term (8 weeks) on (1) 12 h/day of 8% HFCS, (2) 12 h/day 10% sucrose, (3) 24 h/day HFCS, all with ad libitum rodent chow, or (4) ad libitum chow alone. Rats with 12-h access to HFCS gained significantly more body weight than animals given equal access to 10% sucrose, even though they consumed the same number of total calories, but fewer calories from HFCS than sucrose.
- Calories In, Calories Out doesn't work (studies variously show that as few as 6% of people who diet actually lose weight long term -- any system that fails that often can't be described as "working"). Google "effectiveness of dieting" for, like, half a million articles.
- There is science showing that people can eat 7000 calories a day and not gain weight and people can eat 700 calories a day and gain weight. No, I'm not going to explain it. Go read Gary Taubes' "Good Calories, Bad Calories". All of it. You can get a copy from Amazon for $10 or so.